Acute exercise and circulating mitochondrial-derived peptides in humans
PubMed
TL;DR
In a randomized 30-person exercise experiment, endurance exercise increased circulating mitochondrial-derived peptides, while resistance exercise did not show the same response.
Randomized human exercise study · 30 participants
What was studied
The question.
Whether acute endurance or resistance exercise changes circulating levels of the mitochondrial-derived peptides humanin and MOTS-c.
How it was conducted
The study design.
Participants were randomized to endurance exercise, resistance exercise or control, with 10 people in each group. Blood and skeletal-muscle samples were collected before and after the intervention.
What it found
Did it actually work?
- Circulating humanin increased significantly after endurance exercise.
- MOTS-c showed a trend toward increasing after endurance exercise.
- The same circulating response was not seen after resistance exercise.
Why it matters
How to read this result.
It provides direct human evidence that endogenous mitochondrial-derived peptides respond to exercise, supporting MOTS-c biology in humans.
Keep in mind
What the study does not prove.
- The study measured naturally occurring endogenous peptides, not injected MOTS-c treatment.
- It does not establish that exogenous MOTS-c improves exercise performance.
Original source
Want to read the original?
We summarize the study here first. The original source is there when you want the full methods, statistics, tables and author discussion.
Open indexed study record